Projects

Mendelian randomisation

Causal inference through the use of genomics to identify putative druggable candidates.

Cardiovascular genetics

Investigations into the genetic architecture of cardiovascular diseases and their risk factors.

Functional genomics

Exploring the functional role of genetic risk loci of cardiovascular diseases and risk factors.

Other work

Other general work on human disease and its genetic and environmental risk factors.

High-throughput imaging

Applying machine-learning for the analysis of pathological slides.

Selected Publications

. Family history and polygenic risk of cardiovascular disease: Independent factors associated with secondary cardiovascular events in patients undergoing carotid endarterectomy. Atherosclerosis, 2020.

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. Alternate approach to stroke phenotyping identifies a genetic risk locus for small vessel stroke. Eur J Hum Genet, 2020.

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. Beyond GWAS in Atrial Fibrillation Genetics. Circ Res, 2020.

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. Genetic Susceptibility Loci for Cardiovascular Disease and Their Impact on Atherosclerotic Plaques. Circ Gen Prec Med, 2018.

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. Polygenic Susceptibility of Aortic Aneurysms Associates to the Diameter of the Aneurysm Sac: the Aneurysm-Express Biobank Cohort. Sci Rep, 2018.

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. Smoking is Associated to DNA Methylation in Atherosclerotic Carotid Lesions. Circ Gen Prec Med, 2018.

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. From lipid locus to drug target through human genomics. Cardiovasc Res, 2018.

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. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet, 2018.

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. Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets. Sci Rep, 2018.

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. Common coding variant in SERPINA1 increases the risk for large artery stroke. PNAS, 2017.

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. Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization. Circ Cardiovasc Genet, 2017.

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. Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype. ATVB, 2016.

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. Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study. JACC; Volume 68, Issue 9, August 2016. DOI: 10.1016/j.jacc.2016.05.092, 2016.

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. Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1. Stroke, 2015.

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. Genome-wide association studies: methodology and interpretation for clinicians. NTvG, 2014.

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Publications

More Publications

Family history and polygenic risk of cardiovascular disease: Independent factors associated with secondary cardiovascular events in patients undergoing carotid endarterectomy

Details PDF Project

Alternate approach to stroke phenotyping identifies a genetic risk locus for small vessel stroke

Details PDF Project

Beyond GWAS in Atrial Fibrillation Genetics

Details PDF Project

Genetic Susceptibility Loci for Cardiovascular Disease and Their Impact on Atherosclerotic Plaques

Details PDF Project

Polygenic Susceptibility of Aortic Aneurysms Associates to the Diameter of the Aneurysm Sac: the Aneurysm-Express Biobank Cohort

Details PDF Project

Grants

Here’s a list of some of my successes (marked with 😁 ) and failures (marked with 🙈), because “the only real mistake is the one from which we learn nothing.” [Henry Ford].

  • DEEP-ENIGMA: DEEP-ENIGMA: a DEEP nEural Network for Image seGMentation to classify and quantify Atherosclerotic disease based on high-resolution scanned histological slides | Grant total: €5,000.- | Received: 😁 | Applied Data Science - Special Interest Groups (Utrecht, Netherlands)
  • ELSIE: ELSIE: EvoLutionary Selection In Epigenetics | Grant total: €5,000.-, in kind contribution | Received: 😁 | Applied Data Science - Special Interest Groups (Utrecht, Netherlands)
  • TO AITION: Investigating mechanisms in CVD-depression comorbidity | Grant total: €473,750.- | Received: 😁 | H2020 (Brussels, Belgium)
  • CONVOCALS: CONVOCALS: a CONVOlutional neural network to predict symptoms and major secondary CArdiovascuLar events based on high-resolution scanned histological Slides | Grant total: €5,000.- | Received: 😁 | Applied Data Science - Special Interest Groups (Utrecht, Netherlands)
  • 401.16.061: The genetics of carotid and aortic gene expression: replicating expression profiles and expression quantitative trait loci in the Athero-Express and Abdominal Aortic Aneurysm Express Biobank Studies | Grant total: € 150,000.- | Received: 🙈 | NWO (Den Haag, Netherlands)
  • CP2013-63: Genotyping of the Abdominal Aortic Aneurysm-Express Biobank Study | Grant total: €50,000.- | Received: 😁 | BBMRI-NL (Leiden, Netherlands)

You can find a complete up-to-date list at orcid.org/0000-0001-6888-1404.

Teaching

I am one of the lecturers for the following courses and years:

You can find the teaching material here at the lectures project.

Ewan Birney – On Genetics as a whole, and PRSs, and Robert Plomin’s book.

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Converting VCF-output from the Michigan Imputation Server to any other format.

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Setting up macOS El Capitan+ with R with tcl-tk using homebrew.

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Setting up macOS El Capitan+ to do Science in 2018 with homebrew.

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Understanding hugo 2 github static site building.

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Contact