18 MRBase

Right, so as I wrote, MRBase is very easy to handle. It is based on the TwoSampleMR package and uses the MRInstruments package to load in all the genetic instruments. The creators of MRBase have curated hundreds of GWAS and molecular QTL studies, and prepared the data for easy use on the website and in the R packages.

Using MRBase we intend to find out whether Type 2 Diabetes (T2D) causes coronary artery disease.

Go ahead, give it a try. Download this file: practical_Mendelian Randomization.pdf and follow the instructions. MRBase; the website is pretty intuitive and with the lecture you had, you should be able to do this.

18.1 The end?

You are almost at the end. Time to return to the previous chapter on post-GWAS analyses 15.